| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870945 | FEBS Letters | 2013 | 8 Pages |
Abstract
Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4Â weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development.
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Authors
Xiaoqing Cao, Jue Wang, Zhenhua Wang, Juan Du, Xin Yuan, Weicong Huang, Jian Meng, Haiyong Gu, Yu Nie, Bingyang Ji, Shengshou Hu, Zhe Zheng,