Article ID Journal Published Year Pages File Type
10870954 FEBS Letters 2013 7 Pages PDF
Abstract
► Huge intron 7 spliced from endogenous dystrophin pre-mRNA was analyzed by RT-PCR. ► The excised lariat intron 7 had a closed loop but it contained gaps in its sequence. ► Two presumed lariats generated from nested introns within intron 7 were detected. ► These RNA products were generated concomitantly with dystrophin pre-mRNA splicing. ► Proposed model: nested introns are spliced before ultimate splicing in huge intron.
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