| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870957 | FEBS Letters | 2013 | 8 Pages |
Abstract
⺠RRM1 oxidation is solely responsible for oxidation-induced TDP-43 aggregations. ⺠Oxidized RRM1 loses nucleic acid-binding activity. ⺠Oxidation-induced RRM1 aggregation is caused by changes in protein conformation. ⺠The molecular basis of oxidation-induced RRM1 aggregation is proposed.
Keywords
EMSANTDTDP-43RRM1FTLDDTNBRRMFAMSECβME6-carboxyfluoresceinRNA-recognition motifRNA recognition motifβ-mercaptoethanolElectrophoretic mobility shift assayamyotrophic lateral sclerosisOxidationAlzheimer’s diseaseALSHuntington’s diseaseNeurodegenerative diseaseParkinson’s diseaseN-terminal domainfrontotemporal lobar degenerationProtein misfoldingSize exclusion chromatography
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Authors
Chung-ke Chang, Ming-hui Chiang, Elsie Khai-Woon Toh, Chi-Fon Chang, Tai-huang Huang,