Article ID Journal Published Year Pages File Type
10870975 FEBS Letters 2013 8 Pages PDF
Abstract
► Six Rho-GEFs are required for serum-induced chemotaxis in MDA-MB-231 cells. ► Knockdown of p63RhoGEF suppresses serum-induced RhoA activation and chemotaxis. ► Knockdown of p63RhoGEF produces multipolar lamellipodia upon serum stimulation. ► p63RhoGEF promotes chemotaxis by limiting lamellipodium formation to one direction.
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