| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870979 | FEBS Letters | 2013 | 8 Pages |
Abstract
⺠Prox1 is critical to lymphangiogenesis and differentiation of other organs during embryogenesis. ⺠A hypoxia-response element (HRE) has been identified at the Prox1 promoter/regulatory region. ⺠Hypoxia induces up-regulation of the Prox1 gene. ⺠HIF-1α and HIF-2α bind to the Prox1 HRE and activate transcription from the Prox1 promoter. ⺠Hypoxia promotes lymphangiogenesis by activating Prox1.
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Authors
Bisheng Zhou, Wenxia Si, Zhenhong Su, Wenbin Deng, Xin Tu, Qing Wang,