| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871018 | FEBS Letters | 2013 | 6 Pages |
Abstract
⺠We developed an easy method to synthesize novel Wnt inhibitors based on the structure of haloquinone. ⺠This allows to design novel inhibitors simply by modifying the functional groups at the backbone. ⺠Two compounds inhibit Wnt/β-Catenin signaling in two independent bona fide Wnt-activity assays. ⺠The new inhibitors block endogenous Wnt-driven transcription. ⺠Symmetrical compounds act as Wnt antagonists, asymmetrical compounds do not.
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Authors
Sonja Halbedl, Marie-Claire Kratzer, Karolin Rahm, Nicoletta Crosta, Kye-Simeon Masters, Jessica Zippert, Stefan Bräse, Dietmar Gradl,