| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871032 | FEBS Letters | 2013 | 8 Pages |
Abstract
The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.
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Authors
Diana M. Mitrea, Richard W. Kriwacki,