Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871075 | FEBS Letters | 2013 | 6 Pages |
Abstract
Human chitotriosidase (HCHT) is a family 18 chitinase that is an innate part of the immune system. We have mapped preferred productive binding modes of chito-oligosaccharide substrates to HCHT and the data show that HCHT has strong binding affinity in the +3 subsite. Moreover, HCHT shows anomer-specific binding affinities in subsites +2 and +3. These features could endorse HCHT with higher endo-activity and a higher transglycosylation potential.
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Authors
Kristine Bistrup Eide, Anne Rita Lindbom, Vincent G.H. Eijsink, Anne Line Norberg, Morten Sørlie,