Article ID Journal Published Year Pages File Type
10871091 FEBS Letters 2013 7 Pages PDF
Abstract
► Tumor suppressor protein VHL decreases the expression of Hedgehog-Gli1 gene. ► VHL represses Gli1-mediated Hedgehog target gene expression. ► VHL interacts directly with Gli1 protein. ► VHL co-localizes with Gli1 in the cytoplasm and disturbs Gli1 nuclear localization. ► These results suggest that VHL may act as a tumor suppressor in some Hedgehog-related cancers.
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Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization
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