| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871124 | FEBS Letters | 2013 | 6 Pages |
Abstract
⺠New insights into the mechanism of action of the anti-diabetic agent sodium tungstate. ⺠Involvement of G-proteins in Ras/ERK activation by tungstate. ⺠Non-canonical signalling pathway leading to the activation of glycogen synthesis. ⺠This new pathway may be exploited as an approach to treat diabetes.
Keywords
PKBGSK3βZDFRTKPTXERKSTZstreptozotocinChoDiabetesSodium tungstateChinese hamster ovary cellspertussis toxinphosphatidyl-inositol-3-kinaseMetabolismMEKZucker diabetic fatty ratsG-proteinprotein kinase Bmitogen-activated protein kinase kinaseMAP kinaseextracellular signal-regulated kinases 1 and 2ChoirGlycogen synthase kinase-3βGlycogenglycogen synthase insulin receptorReceptor Tyrosine Kinase
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Authors
Delia Zafra, Laura Nocito, Jorge DomÃnguez, Joan J. Guinovart,