Article ID Journal Published Year Pages File Type
10871144 FEBS Letters 2012 6 Pages PDF
Abstract
► Urate oxidase is identified as a substrate of SIRT5 protein. ► Urate oxidase is located both in mitochondria and peroxisomes. ► Urate oxidase is deacetylated and activated in liver mitochondria of SIRT5 Tg mice. ► In vitro-synthesized urate oxidase is acetylated when incubated with mitochondria.
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