Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871157 | FEBS Letters | 2012 | 8 Pages |
Abstract
⺠Orexin A stimulates 3T3-L1 cells proliferation, and protects them from apoptosis. ⺠Mitogenic and antiapoptotic effects of orexin A are conferred via ERK1/2 signaling. ⺠Orexin A fails to enhance 3T3-L1 cells differentiation into mature adipocytes..
Keywords
HprtIGF-1SGMPPARγFCSOXADEXAOROIBMXPI3K3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide3-isobutyl-1-methylxanthine5-bromo-2′-deoxyuridineC/EBPαcAMPERK1/2MTTCyclic adenosine monophosphateAdipocyteAktorexin ABrdUProliferationApoptosisIn vitroDexamethasoneOil red Ofetal calf seruminsulin-like growth factor 1Phosphatidylinositol 3-kinaseFibroblastSDMHypoxanthine–guanine phosphoribosyltransferaseCCAAT/enhancer binding protein alphaprotein kinase B (PKB)extracellular signal-regulated kinase 1/2Peroxisome proliferator-activated receptor gamma
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Authors
M. Skrzypski, P. Kaczmarek, T.T. Le, T. Wojciechowicz, E. PruszyÅska-Oszmalek, D. Szczepankiewicz, M. Sassek, A. Arafat, B. Wiedenmann, K.W. Nowak, M.Z. Strowski,