MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway

Article ID	Journal	Published Year	Pages	File Type
10871158	FEBS Letters	2012	8 Pages	PDF

Abstract

âº miR-497 is a novel regulator of MEK1 via binding to its 3â²UTR. âº RAF1 and ERK1, but not ERK2, were also targeted by miR-497. âº miR-497 repressed phosphorylation cascade of ERK pathway upon IL-1 stimulation. âº miR-497 indirectly activated P38 pathway upon IL-1 stimulation. âº IL-1 induced IL-6 transcription was impaired by miR-497.

Keywords

AP-1 Mitogen-activated protein kinase 14 MEK1 c-jun amino-terminal kinase miR-497 MAP kinase kinase p38 ERK IL-6 Jnk IL-1 qPCR 3′ untranslated region 3′UTR MAPK NFκB interleukin Raf1 nuclear factor κB MEK ERK pathway MicroRNA MiRNA mitogen-activated protein kinase Jun proto-oncogene extracellular signal-regulated kinase