| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871162 | FEBS Letters | 2012 | 7 Pages |
Abstract
⺠Sim3, a CenH3 histone chaperone, can replace the function of Asf1, a H3 histone chaperone, in fission yeast. ⺠Overexpression of Sim3 suppressed the temperature sensitive phenotype of asf1-33 and asf1-30 mutants. ⺠Sim3 suppressed the defect in chromatin structure, and prevented the accumulation of DNA damage in asf1-33. ⺠Îsim3 and asf1-33 is synthetic lethal. ⺠Sim3 may play a role as H3 histone chaperone in addition to its role as a CenH3 histone chaperone.
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Authors
Katsuhiro Tanae, Tomitaka Horiuchi, Takuya Yamakawa, Yuzy Matsuo, Makoto Kawamukai,