| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871167 | FEBS Letters | 2012 | 5 Pages |
Abstract
⺠APH(3â²)-IIIa is a bacterial kinase responsible for antibiotics resistance. ⺠Release of ADP is the rate limiting step of Kanamycin A phosphorylation. ⺠An ADP-enzyme complex is the main steady state intermediate. ⺠A strategy to prevent the phosphorylation of aminoglycosides is uncompetitive inhibition. ⺠A good target for uncompetitive inhibitors is the ADP-enzyme complex.
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Authors
Perrine Lallemand, Nadia Leban, Simone Kunzelmann, Laurent Chaloin, Engin H. Serpersu, Martin R. Webb, Tom Barman, Corinne Lionne,