Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871225 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠CCN2 bound to the receptor of fibroblast growth factor 2 (FGFR2) and facilitated the binding of FGFR2 to its ligands, FGF2 and FGF4. ⺠By binding to FGFR2, CCN2 augmented the phosphorylation of ERK induced by FGF signaling. ⺠Osteoblastic differentiation was enhanced under the collaboration of CCN2 and FGF2.
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Authors
Eriko Aoyama, Satoshi Kubota, Masaharu Takigawa,