Article ID Journal Published Year Pages File Type
10871255 FEBS Letters 2012 6 Pages PDF
Abstract
► We identify RBM5 as a regulator factor promoting AID exon 4 skipping. ► A weak 3′-splice site of intron 3 is required for RBM5-stimulated exon 4 skipping. ► RBM5 directly interacts with intron 3 of AID pre-mRNA. ► RBM5 competes with U2AF65 for the binding to the polypyrimidine tract in vitro.
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Life Sciences Agricultural and Biological Sciences Plant Science
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RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract
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