| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871287 | FEBS Letters | 2012 | 8 Pages |
Abstract
⺠We demonstrate that HCV core protein (Core) impairs growth in budding yeast. ⺠We identify HSP90 inhibitors as compounds that restore the yeast growth. ⺠HSC90 can confer stability of the nascent but not the pre-existing Core in yeast. ⺠An organelle interaction domain of the Core is crucial for the growth retardation. ⺠The yeast system may be utilized to select compounds that can reduce Core stability.
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Authors
Naoko Kubota, Yasutaka Inayoshi, Naoko Satoh, Takashi Fukuda, Kenta Iwai, Hiroshi Tomoda, Michinori Kohara, Kazuhiro Kataoka, Akira Shimamoto, Yasuhiro Furuichi, Akio Nomoto, Akira Naganuma, Shusuke Kuge,