| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871295 | FEBS Letters | 2012 | 9 Pages |
Abstract
⺠We report the inhibitory effect of plasmin in the presence of Alendronate upon proMMP-9. ⺠Alendronate promotes non-reversible plasmin-mediated MMP-9 inactivation. ⺠Alendronate plus plasmin degrades MMP-9 to inactive catalytic site and hemopexin-domain fragments. ⺠Hemopexin-domain generated by plasmin plus Alendronate inhibits MMP-9 activity. ⺠New rational for Alendronate use in MMP-9/plasmin-dependent pathology.
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Authors
Antonietta R. Farina, Lucia Cappabianca, Natalia Di Ianni, Pierdomenico Ruggeri, Marzia Ragone, Stefania Merolle, Alberto Gulino, Andrew R. Mackay,