Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein Î±

Article ID	Journal	Published Year	Pages	File Type
10871316	FEBS Letters	2012	6 Pages	PDF

Abstract

âº Substrates of prolyl oligopeptidase (POP) and fibroblast activation protein Î± (FAP). âº Bias against charged residues at the P1' and P2' positions for POP-specific substrates. âº FAP-specific substrates preferred charged residues at the P1' and P2' positions. âº No serine or threonine residues at P1' and P2' positions for FAP-specific substrates. âº In synthetic format, some physiologic substrates of FAP are also cleaved by POP.

Keywords

ZPP DPA APCE MCA MALDI-TOF DPPIV FAP ACN DMSO Acetonitrile Depression Alzheimer’s disease Parkinson’s disease dipeptidyl peptidase IV Dimethylsulfoxide Cancer Cognition pop Fibroblast activation protein Fibroblast activation protein α prolyl oligopeptidase prolyl endopeptidase