| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871317 | FEBS Letters | 2012 | 9 Pages |
Abstract
⺠We dissect the roles of the individual domains of CHD4. ⺠The chromo domains bind DNA while the PHD domains modulate this activity. ⺠ATPase and chromo domains increase the histone tail binding affinity of PHD domains. ⺠PHD and chromo domains are required for DNA stimulated ATPase activity. ⺠SAXS shape reconstruction delineates intramolecular interactions between domains.
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Authors
Rosa Morra, Benjamin M. Lee, Heather Shaw, Roman Tuma, Erika J. Mancini,