| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871376 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠Anti-metastatic efficacy of TF14016, a CXCR4 inhibitor, on SCLC was examined. TF14016 treatment significantly suppressed pulmonary metastases of SCLC cells in mice. ⺠VEGF expression in metastasized SCLC cells was suppressed by TF14016-treatment. ⺠CD31-positive microvessels in metastatic foci were reduced by TF14016 treatment. ⺠CXCR4 could be a target for anti-metastatic and anti-angiogenic therapy in SCLC.
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Authors
Yasushi Otani, Takashi Kijima, Satoshi Kohmo, Shinya Oishi, Toshiyuki Minami, Izumi Nagatomo, Ryo Takahashi, Haruhiko Hirata, Mayumi Suzuki, Koji Inoue, Yoshito Takeda, Hiroshi Kida, Isao Tachibana, Nobutaka Fujii, Atsushi Kumanogoh,