| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871378 | FEBS Letters | 2012 | 5 Pages |
Abstract
⺠We studied biosynthesis of the cardiovascular risk factor homoarginine in humans. ⺠Arginine:glycine amidinotransferase (AGAT) is a key enzyme in creatine synthesis. ⺠Healthy lymphoblasts can synthesize homoarginine from arginine and lysine. ⺠In AGAT-deficient lymphoblasts homoarginine synthesis was undetectable. ⺠Promiscuous activity of AGAT plays a pivotal role in homoarginine synthesis.
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Authors
Mariska Davids, Joseph D.T. Ndika, Gajja S. Salomons, Henk J. Blom, Tom Teerlink,