Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871379 | FEBS Letters | 2012 | 7 Pages |
Abstract
⺠The Tyr-Tyr-Asn motif supports activation of the Ras-Erk pathway. ⺠Grb2- and ShcA-binding sites display somewhat different abilities to activate the Ras-Erk pathway. ⺠Grb2- and ShcA-binding sites have similar abilities to activate the PI 3-kinase-Akt pathway. ⺠NGF receptor-dependent activation of the PI 3-kinase-Akt pathway depends on the Tyr 490. ⺠Grb2- and ShcA-binding sites display dramatically different abilities to turn on DNA synthesis.
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Authors
Shinichiro Oku, Talitha van der Meulen, Jeremy Copp, Gary Glenn, Peter van der Geer,