Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871388 | FEBS Letters | 2012 | 8 Pages |
Abstract
⺠Cyclooxygenases (COX) convert arachidonic acid to MDA and 15(S)-8-iso-PGF2α. ⺠Glutathione (GSH) promotes COX-dependent MDA and 15(S)-8-iso-PGF2α formation. ⺠Mechanisms are proposed for the formation of MDA and 15(S)-8-iso-PGF2α. ⺠The utility of MDA and 15(S)-8-iso-PGF2α as oxidative stress biomarkers is challenged.
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Authors
Dimitrios Tsikas, Maria-Theresia Suchy, Jonas Niemann, Paschalis Tossios, Yessica Schneider, Sabine Rothmann, Frank-Mathias Gutzki, Jürgen C. Frölich, Dirk O. Stichtenoth,