| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871401 | FEBS Letters | 2012 | 7 Pages |
Abstract
⺠We established an integrated analysis system of amplicons. ⺠Applying this system to 17q12-21 amplicon, we identified GRB7 as an ERBB2-dependent oncogene. ⺠GRB7 modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt. ⺠BPS domain of GRB7 suppresses, while, the other domains are required for GRB7-mediated transforming activity.
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Authors
Makoto Saito, Yukiko Kato, Emi Ito, Jiro Fujimoto, Kosuke Ishikawa, Ayano Doi, Kentaro Kumazawa, Atsuka Matsui, Shiori Takebe, Takaomi Ishida, Sakura Azuma, Hiromi Mochizuki, Yoshifumi Kawamura, Yuka Yanagisawa, Reiko Honma, Jun-ichi Imai,