| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871402 | FEBS Letters | 2012 | 4 Pages |
Abstract
⺠Ras-GTP adopts two conformations, “inactive” state 1 and “active” state 2. ⺠State 1 crystal structures of H-Ras wild type together with its oncogenic mutants were determined for the first time. ⺠State 1 crystal structures show two surface pockets, a potential target for selective inhibitor development. ⺠State 1 crystal structures provide a structure basis for low GTPase activity of state 1.
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Authors
Shin Muraoka, Fumi Shima, Mitsugu Araki, Tomoko Inoue, Akiko Yoshimoto, Yuichi Ijiri, Nobuaki Seki, Atsuo Tamura, Takashi Kumasaka, Masaki Yamamoto, Tohru Kataoka,