Article ID Journal Published Year Pages File Type
10871415 FEBS Letters 2012 7 Pages PDF
Abstract
► Charge repulsion in the HIP1 coiled-coil interface increases molecular plasticity.► Stabilized HIP1 aggregates into large particles. ► Stability mutations in HIP1 impact the immunoprecipitation of huntingtin. ► Presence of aggregated HIP1 causes cell death via necrotic and apoptotic pathways.
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Life Sciences Agricultural and Biological Sciences Plant Science
Preview
Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death
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