| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871458 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠Loops are the main evolvable hotspots in TEMs and proteins in general. ⺠The generation of more complex functions requires more mutations to accumulate. ⺠Many new-function mutations are already present in the simpler enzymes. ⺠New-function and stability-restoring substitutions cluster to two groups of sites. ⺠Functional changes upon mutation can be predicted from physicochemical properties.
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Authors
Luciano A. Abriata, Merijn L. M. Salverda, Pablo E. Tomatis,