Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871474 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠NUPR1 regulates p21 in p53-competent breast cancer cells. ⺠We have studied chemoresistance induced by NUPR1 in p53-null triple-negative breast cancer cells. ⺠We also have investigated modalities to overcome this chemoresistance. ⺠We show a NUPR1-PI-3-K/Akt phospho-p21 axis that enhances chemoresistance in breast cancer cells.
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Authors
Andrew J. Vincent, Suping Ren, Lillianne G. Harris, Daniel J. Devine, Rajeev S. Samant, Oystein Fodstad, Lalita A. Shevde,