Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871477 | FEBS Letters | 2012 | 4 Pages |
Abstract
⺠Heterozygous EZH2 A687 V mutation is associated with lymphoma. ⺠A687 V EZH2 mutant shown to be active with altered substrate specificity. ⺠Mutation changes substrate specificity and H3K27me1 to H3K27me2 reaction is enhanced.
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Authors
Christina R. Majer, Lei Jin, Margaret Porter Scott, Sarah K. Knutson, Kevin W. Kuntz, Heike Keilhack, Jesse J. Smith, Mikel P. Moyer, Victoria M. Richon, Robert A. Copeland, Tim J. Wigle,