Article ID Journal Published Year Pages File Type
10871483 FEBS Letters 2012 8 Pages PDF
Abstract
► We clarify the function and roles of PGRN in muscle growth and its association with IGF-1 signaling. ► We demonstrate that PGRN stimulates mouse C2C12 myotube hypertrophy via the PI3K/Akt/mTOR signaling pathway. ► We demonstrate the function of PGRN in muscle growth and indicated a compensative role for PGRN and IGF-1 signaling.
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Life Sciences Agricultural and Biological Sciences Plant Science
Preview
Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway
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