Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871486 | FEBS Letters | 2012 | 5 Pages |
Abstract
⺠First direct probe AFM imaging of single molecules of E180G mutant tropomyosin. ⺠E180G mutation markedly reduces persistence length, implying increased flexibility. ⺠Mutant persistence length is less than the length of a tropomyosin molecule. ⺠Flexibility implies spatial gradient of partial activation within one regulatory unit. ⺠Increased flexibility explains many aspects of altered cardiac dysfunction.
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Authors
Campion K.P. Loong, Huan-Xiang Zhou, P. Bryant Chase,