| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871495 | FEBS Letters | 2011 | 7 Pages |
Abstract
⺠Human Fbw7alpha is phosphorylated at Ser227 in a PI3K-dependent manner. ⺠Subcellular localization and known interactions of Fbw7 are not affected. ⺠Ser227 phosphorylation stabilizes Fbw7 and enhances substrate degradation. ⺠Ser227 phosphorylation regulates Fbw7 to fine-tune substrate levels and activity.
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Authors
Christina Schülein, Martin Eilers, Nikita Popov,