Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871509 | FEBS Letters | 2011 | 8 Pages |
Abstract
⺠WT1 expression in K562 leukemic cells was suppressed by pure curcumin through disruption of a WT1 auto-regulatory loop. ⺠Pure curcumin remodeled the WT1 promoter, resulting in loss of WT1 transcription and decreased WT1 expression. ⺠Curcumin inhibition of WT1 was independent of protein and mRNA degradation pathways. ⺠The inhibitory effect of curcumin was mediated through inhibition of the PKCα signaling pathway. ⺠WT1 over-expression reversed pure curcumin-mediated growth inhibition of K562 cells.
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Authors
Suwanna Semsri, Sheryl R. Krig, Lakmal Kotelawala, Colleen A. Sweeney, Songyot Anuchapreeda,