| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871512 | FEBS Letters | 2011 | 8 Pages |
Abstract
⺠α-Secretase activity can be modulated by two nucleotide receptors in N2a cells. ⺠Activation of a P2X7 receptor reduces α-secretase-dependent APP cleavage. ⺠α-Secretase proteolytic activity is enhanced by activation of a P2Y2 receptor. ⺠P2X7R and P2Y2R could be novel therapeutic targets in Alzheimer's disease.
Keywords
CTFGM6001Neuro-2aBBGBrilliant Blue GN2aBACEBzATPAPPAβshRNAβ-secretase3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideMTTsmall hairpin RNAα-SecretaseADAMAlzheimer’s diseasea disintegrin and metalloproteaseC-terminal fragmentamyloid precursor proteinamyloid-β peptideP2X7 receptorP2Y2 receptor
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Authors
Miriam León-Otegui, Rosa Gómez-Villafuertes, Juan Ignacio DÃaz-Hernández, Miguel DÃaz-Hernández, Maria Teresa Miras-Portugal, Javier Gualix,