Article ID Journal Published Year Pages File Type
10871517 FEBS Letters 2011 6 Pages PDF
Abstract
► We examined the effect of HVEM deficiency on obesity-induced inflammation and complications. ► HVEM-deficient mice or wild type mice were fed a high-fat diet (HFD). ► HFD-fed HVEM-deficient mice elicited a reduction in the number of macrophage/T cells infiltrated into adipose tissue. ► Proinflammatory cytokine levels were also decreased in the adipose tissue of HFD-fed HVEM. ► Glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice.
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