| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871528 | FEBS Letters | 2011 | 5 Pages |
Abstract
⺠siRNAs destabilized by mismatches introduced to the central part of the duplex. ⺠Selective protection of nuclease-sensitive sites in siRNA by 2â²-O-methyl analogs. ⺠Wobble pairs are better tolerated by RNAi machinery than mismatches. ⺠GU wobble pairs in the central part of the duplex can enhance silencing activity.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Natalya S. Petrova, Mariya I. Meschaninova, Alya G. Venyaminova, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya,