Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871528 | FEBS Letters | 2011 | 5 Pages |
Abstract
⺠siRNAs destabilized by mismatches introduced to the central part of the duplex. ⺠Selective protection of nuclease-sensitive sites in siRNA by 2â²-O-methyl analogs. ⺠Wobble pairs are better tolerated by RNAi machinery than mismatches. ⺠GU wobble pairs in the central part of the duplex can enhance silencing activity.
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Authors
Natalya S. Petrova, Mariya I. Meschaninova, Alya G. Venyaminova, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya,