| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871536 | FEBS Letters | 2011 | 5 Pages |
Abstract
⺠Lamprey angiotensinogen is an effective thrombin inhibitor, in contrast to all orthologs. ⺠Heparin enhances thrombin inhibition >800-fold with a bell-shaped dose-response curve. ⺠Dermatan sulfate stimulates thrombin/lamprey angiotensinogen interaction differently. ⺠Angiotensinogen and heparin cofactor II are derived from a common ancestor. ⺠An evolutionary scenario of thrombin control by serpins in vertebrates is presented.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Yunjie Wang, Hermann Ragg,