| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871541 | FEBS Letters | 2012 | 5 Pages |
Abstract
⺠Hyperhomocysteinemia has been identified as an independent risk factor for the development of Alzheimer's disease. ⺠Homocysteine can be converted to Hcy-thiolactone, which can alter protein structure by N-homocysteinylation. ⺠We examine changes in the structure and cytotoxicity of N-homocysteinylated amyloid beta peptide aggregation. ⺠The modification induces a change in structure and increases its tendency to form toxic aggregates.
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Authors
Sirus Khodadadi, Gholam Hossein Riazi, Shahin Ahmadian, Elham Hoveizi, Oveis Karima, Hassan Aryapour,