cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation

Article ID	Journal	Published Year	Pages	File Type
10871545	FEBS Letters	2012	5 Pages	PDF

Abstract

âº Capacitation and cyclic nucleotides increase the macroscopic current in mouse sperm. âº There are subpopulations of sperm depending on their response to cyclic nucleotides. âº CNG channels are physiologically active in the mature mouse sperm. âº Sperm CNG channels have different sensitivity between cGMP and cAMP. âº CNG channels participate in sperm capacitation providing an entry pathway for Ca2+.

Keywords

CNG EGTA cGMP PKG 8-bromoguanosine 3′,5′-cyclic monophosphate 8-bromoadenosine 3′,5′-cyclic monophosphate 8Br-cAMP cAMP Cyclic adenosine monophosphate ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid Sperm capacitation cyclic guanosine monophosphate cyclic nucleotide-gated CNG channel