Article ID Journal Published Year Pages File Type
10871551 FEBS Letters 2012 6 Pages PDF
Abstract
► We studied the role of 5-HT2B receptor (5-HT2BR) in cardiac hypertrophy in rats. ► Isoproterenol infusion for 28 days was used to induce cardiac hypertrophy in rats. ► 5-HT2BR protein overexpression was seen in isoproterenol-induced cardiac hypertrophy. ► 5-HT2BR blockade ameliorated hypertrophy along with phosphorylation of Akt/GSK-3β/eNOS. ► GSK-3β inhibition further amplified the protective effect of 5-HT2BR blockade.
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Life Sciences Agricultural and Biological Sciences Plant Science
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Phosphorylation of Akt/GSK-3β/eNOS amplifies 5-HT2B receptor blockade mediated anti-hypertrophic effect in rats
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