| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871559 | FEBS Letters | 2012 | 8 Pages |
Abstract
⺠The transmembrane protease ADAM17 recognizes more than 70 substrates. ⺠The minimal requirement for recognition of two substrates was identified. ⺠The IL-1RII and the IL-6R are recognized by the membrane-proximal domain. ⺠In this respect the transmembrane- and cytoplasmic regions are dispensable. ⺠No interaction between TNF-α and the membrane-proximal domain has been detected.
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Authors
Inken Lorenzen, Juliane Lokau, Stefan Düsterhöft, Ahmad Trad, Christoph Garbers, Jürgen Scheller, Stefan Rose-John, Joachim Grötzinger,