Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871565 | FEBS Letters | 2012 | 6 Pages |
Abstract
⺠PUB domain of PNGase binds to HR23-UBL more preferentially than ubiquitin chains. ⺠3D model of the PUB-UBL complex is presented based on NMR data. ⺠The PUB-UBL complex is mediated by electrostatic interactions. ⺠PUB binds the UBL surface involved in intramolecular interaction with HR23-UBA. ⺠PNGase-PUB could serve as a putative activator of HR23 in ERAD.
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Authors
Yukiko Kamiya, Yoshinori Uekusa, Akira Sumiyoshi, Hiroaki Sasakawa, Takeshi Hirao, Tadashi Suzuki, Koichi Kato,