Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871588 | FEBS Letters | 2012 | 6 Pages |
Abstract
RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches are shedding some light on this interesting aspect of gene transcription. In this review, we briefly summarise these new findings, comment about some results recently obtained in our laboratory, and propose a new model for the influence of the chromatin context on RNA polymerase II backtracking.
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Authors
Fernando Gómez-Herreros, Lola de Miguel-Jiménez, Gonzalo Millán-Zambrano, Xenia Peñate, Lidia Delgado-Ramos, Mari Cruz Muñoz-Centeno, Sebastián Chávez,