Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10871603 | FEBS Letters | 2012 | 7 Pages |
Abstract
Pseudomonas putida strains are prevalent in a variety of pristine and polluted environments. The genome of the solvent-tolerant P. putida strain DOT-T1E which thrives in the presence of high concentrations of monoaromatic hydrocarbons, contains a circular 6.3Â Mbp chromosome and a 133Â kbp plasmid. Omics information has been used to identify the genes and proteins involved in solvent tolerance in this bacterium. This strain uses a multifactorial response that involves fine-tuning of lipid fluidity, activation of a general stress-response system, enhanced energy generation, and induction of specific efflux pumps that extrude solvents to the medium. Local and global transcriptional regulators participate in a complex network of metabolic functions, acting as the decision makers in the response to solvents.
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Authors
Zulema Udaondo, Estrella Duque, Matilde Fernández, Lázaro Molina, Jesús de la Torre, Patricia Bernal, José-Luis Niqui, Cecilia Pini, Amalia Roca, Miguel A. Matilla, M. Antonia Molina-Henares, Hortencia Silva-Jiménez, Gloria Navarro-Avilés,