| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871667 | FEBS Letters | 2011 | 11 Pages |
Abstract
⺠HCELL, a sialofucosylated glycoform of CD44, is the most potent E-/L-selectin ligand on human cells. ⺠Metastasis is facilitated by selectin-mediated interactions. ⺠E-Selectin facilitates metastasis to the liver, lungs and bone marrow. ⺠HCELL is the principal protein scaffold for E-selectin ligands on cancer cells. ⺠HCELL mediates interaction between cancer cells and endothelial cells, leukocytes and platelets.
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Authors
Pieter P. Jacobs, Robert Sackstein,