| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871670 | FEBS Letters | 2011 | 11 Pages |
Abstract
⺠Nm23-H1 is one of the most studied metastatic suppressor proteins with clinical potential for therapies against highly mestatic cancers. ⺠Nm23-H1 has three major enzymatic functions, which are nucleoside diphosphate kinase (NDPK), histidine kinase and 3'-5'exonuclease activities. ⺠A large number of cellular proteins bind to and critically modulate the metastatic potential of Nm23-H1. ⺠Several oncogenic viruses, including EBV, KSHV and HPV encode antigens which negatively regulate Nm23-H1 associated metastatic functions to facilitate cell motility as well as cancer progression.
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Authors
Abhik Saha, Erle S. Robertson,