| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10871680 | FEBS Letters | 2011 | 5 Pages |
Abstract
⺠Chk2 inhibitors are designed to extend into a hydrophobic pocket in the kinase. ⺠X-ray co-crystal structures reveal the modes of binding by the modified inhibitors. ⺠The inhibitors occupy the hydrophobic pocket and their specificity is improved.
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Authors
George T. Lountos, Andrew G. Jobson, Joseph E. Tropea, Christopher R. Self, Guangtao Zhang, Yves Pommier, Robert H. Shoemaker, David S. Waugh,