Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated

Article ID	Journal	Published Year	Pages	File Type
10871682	FEBS Letters	2011	4 Pages	PDF

Abstract

âº Known human phosphodiesterases do not hydrolyze cCMP. âº Several human phosphodiesterases effectively hydrolyze cUMP. âº The study points to a role of cCMP and cUMP as second messengers.

Keywords

CIMP Xanthosine 5′-monophosphate uridine 3′,5′-cyclic monophosphate nucleoside 3′,5′-cyclic monophosphate inosine 3′,5′-cyclic monophosphate Thymidine 5′-monophosphate XMP CTMP cCMP cNMP UMP AMP TMP cGMP PDE GMP IMP CMP inosine 5′-monophosphate cAMP guanosine 3′,5′-cyclic monophosphate HPLC–MS uridine 5′-monophosphate adenosine 3′,5′-cyclic monophosphate adenosine 5′-monophosphate cUMP cytidine 3′,5′-cyclic monophosphate cytidine 5′-monophosphate Phosphodiesterase Cyclic nucleotide Guanosine 5′-monophosphate